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1

Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis

Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova-Kostova, Edward J. Calabrese

Journal:

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

2

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite, Laura, Coulombe, Pierre A., Schäfer, Matthias, Dinkova-Kostova, Albena T., Paus, Ralf, Haslam, Iain S.

Journal:

Year:

2017

Language:

english

File:

PDF, 671 KB

english, 2017

3

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Yoko, Fahey, Jed W., Dinkova-Kostova, Albena T., Kensler, Thomas W.

Journal:

Year:

2019

Language:

english

File:

PDF, 3.02 MB

english, 2019

4

Glucosinolates and isothiocyanates in health and disease

Albena T. Dinkova-Kostova, Rumen V. Kostov

Journal:

Trends in Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 842 KB

english, 2012

5

Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents(1)

Zheng, Suqing, Santosh Laxmi, Y. R., David, Emilie, Dinkova-Kostova, Albena T., Shiavoni, Katherine H., Ren, Yanqing, Zheng, Ying, Trevino, Isaac, Bumeister, Ronald, Ojima, Iwao, Wigley, W. Christian,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

6

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

Albena T Dinkova-Kostova, Paul Talalay

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 91 KB

english, 2000

7

Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

Dinkova-Kostova, Albena

Journal:

Year:

2008

Language:

english

File:

PDF, 343 KB

english, 2008

8

Rhodiola roseaL.: from golden root to green cell factories

Marchev, Andrey S., Dinkova-Kostova, Albena T., György, Zsuzsanna, Mirmazloum, Iman, Aneva, Ina Y., Georgiev, Milen I.

Journal:

Phytochemistry Reviews

Year:

2016

Language:

english

File:

PDF, 848 KB

english, 2016

9

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova-Kostova, Ivo Iavicoli, Rosanna Di Paola, Aleardo Koverech, Salvatore Cuzzocrea, Enrico Rizzarelli, Edward J. Calabrese

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2012

Language:

english

File:

PDF, 2.02 MB

english, 2012

10

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

Roubalová, Lenka, Biedermann, David, Papoušková, Barbora, Vacek, Jan, Kuzma, Marek, Křen, Vladimír, Ulrichová, Jitka, Dinkova-Kostova, Albena T., Vrba, Jiří

Journal:

Chemico-Biological Interactions

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

11

NRF2 as an Emerging Therapeutic Target

Copple, Ian M., Dinkova-Kostova, Albena T., Kensler, Thomas W., Liby, Karen T., Wigley, W. Christian

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

12

Curcumin and the cellular stress response in free radical-related diseases

Vittorio Calabrese, Timothy E. Bates, Cesare Mancuso, Carolin Cornelius, Bernardo Ventimiglia, Maria Teresa Cambria, Laura Di Renzo, Antonino De Lorenzo, Albena T. Dinkova-Kostova

Journal:

Molecular Nutrition & Food Research

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

13

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

Dinkova-Kostova, Albena T., Baird, Liam, Holmström, Kira M., Meyer, Colin J., Abramov, Andrey Y.

Journal:

Biochemical Society Transactions

Year:

2015

Language:

english

File:

PDF, 572 KB

english, 2015

14

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Ying, Gilmour, Amy, Ahn, Young-Hoon, de la Vega, Laureano, Dinkova-Kostova, Albena T.

Journal:

Year:

2019

Language:

english

File:

PDF, 655 KB

english, 2019

15

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

Shapiro, Theresa A., Fahey, Jed W., Dinkova-Kostova, Albena T., Holtzclaw, W. David, Stephenson, Katherine K., Wade, Kristina L., Ye, Lingxiang, Talalay, Paul

Journal:

Nutrition and Cancer

Year:

2006

Language:

english

File:

PDF, 839 KB

english, 2006

16

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

Dinkova-Kostova, Albena T., Kostov, Rumen V., Canning, Peter

Journal:

Archives of Biochemistry and Biophysics

Year:

2016

Language:

english

File:

PDF, 1.82 MB

english, 2016

17

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

Bartolome, Fernando, Esteras, Noemi, Martin-Requero, Angeles, Boutoleau-Bretonniere, Claire, Vercelletto, Martine, Gabelle, Audrey, Le Ber, Isabelle, Honda, Tadashi, Dinkova-Kostova, Albena T., Hardy,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 4.21 MB

english, 2017

18

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Arafa, Reem, Ghorab, Mostafa, Alsaid, Mansour, Higgins, Maureen, Dinkova-Kostova, Albena, Shahat, Abdelaaty, Elghazawy, Nehal

Journal:

Drug Design Development and Therapy

Year:

2016

Language:

english

File:

PDF, 933 KB

english, 2016

19

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

Calabrese, Vittorio, Cornelius, Carolin, Dinkova-Kostova, Albena T., Calabrese, Edward J., Mattson, Mark P.

Journal:

Antioxidants & Redox Signaling

Year:

2010

Language:

english

File:

PDF, 1.94 MB

english, 2010

20

The cytoprotective role of the Keap1–Nrf2 pathway

Liam Baird, Albena T. Dinkova-Kostova

Journal:

Archives of Toxicology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

21

Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein †

Dinkova-Kostova, Albena T., Holtzclaw, W. David, Wakabayashi, Nobunao

Journal:

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

22

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

Bensasson, René V., Dinkova-Kostova, Albena T., Zheng, Suqing, Saito, Akira, Li, Wei, Zoete, Vincent, Honda, Tadashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 491 KB

english, 2016

23

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

Albena T. Dinkova-Kostova, Paul Talalay

Journal:

Molecular Nutrition & Food Research

Year:

2008

Language:

english

File:

PDF, 978 KB

english, 2008

24

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

David R Gang, Michael A Costa, Masayuki Fujita, Albena T Dinkova-Kostova, Huai-Bin Wang, Vincent Burlat, William Martin, Simo Sarkanen, Laurence B Davin, Norman G Lewis

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 3.82 MB

english, 1999

25

The emerging role of Nrf2 in mitochondrial function

Dinkova-Kostova, Albena T., Abramov, Andrey Y.

Journal:

Free Radical Biology and Medicine

Year:

2015

Language:

english

File:

PDF, 1011 KB

english, 2015

26

NAD(P)H : Quinone Oxidoreductase 1 Inducer Activity of Some Saudi Arabian Medicinal Plants

Shahat, Abdelaaty, Alsaid, Mansour, Alyahya, Muhammad, Higgins, Maureen, Dinkova-Kostova, Albena

Journal:

Year:

2013

Language:

english

File:

PDF, 208 KB

english, 2013

27

The design, synthesis and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

Bertrand, Hélène, Schaap, Marjolein, Baird, Liam, Georgakopoulos, Nikolaos D., Fowkes, Adrian, Thiollier, Clarisse, Kachi, Hiroko, Dinkova-Kostova, Albena T., Wells, Geoffrey

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.73 MB

english, 2015

28

Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma

Knatko, Elena V., Praslicka, Brandon, Higgins, Maureen, Evans, Alan, Purdie, Karin J., Harwood, Catherine A., Proby, Charlotte M., Ooi, Aikseng, Dinkova-Kostova, Albena T.

Journal:

Cancer Prevention Research

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

29

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

Knatko, Elena V., Higgins, Maureen, Fahey, Jed W., Dinkova-Kostova, Albena T.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 690 KB

english, 2016

30

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, John D., Dinkova-Kostova, Albena T.

Journal:

Trends in Biochemical Sciences

Year:

2014

Language:

english

File:

PDF, 1.48 MB

english, 2014

31

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

Kostov, Rumen V., Knatko, Elena V., McLaughlin, Lesley A., Henderson, Colin J., Zheng, Suqing, Huang, Jeffrey T.-J., Honda, Tadashi, Dinkova-Kostova, Albena T.

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 722 KB

english, 2015

32

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

Dayalan Naidu, Sharadha, Dinkova-Kostova, Albena T.

Journal:

Year:

2020

File:

PDF, 1.84 MB

2020

33

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

René V. Bensasson, Vincent Zoete, Gaston Berthier, Paul Talalay, Albena T. Dinkova-Kostova

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 666 KB

english, 2010

34

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells

Roubalová, Lenka, Dinkova-Kostova, Albena T., Biedermann, David, Křen, Vladimír, Ulrichová, Jitka, Vrba, Jiří

Journal:

Year:

2017

Language:

english

File:

PDF, 591 KB

english, 2017

35

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Ying Zhang, Young-Hoon Ahn, Ivor J. Benjamin, Tadashi Honda, Ronald J. Hicks, Vittorio Calabrese, Philip A. Cole, Albena T. Dinkova-Kostova

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 896 KB

english, 2011

36

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

Albena T. Dinkova-Kostova, Stephanie N. Jenkins, Scott L. Wehage, David L. Huso, Andrea L. Benedict, Katherine K. Stephenson, Jed W. Fahey, Hua Liu, Karen T. Liby, Tadashi Honda, Gordon W. Gribble, Mi

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 480 KB

english, 2008

37

Nitric Oxide in Cell Survival: A Janus Molecule

Calabrese, Vittorio, Cornelius, Carolin, Rizzarelli, Enrico, Owen, Joshua B., Dinkova-Kostova, Albena T., Butterfield, D. Allan

Journal:

Antioxidants & Redox Signaling

Year:

2009

Language:

english

File:

PDF, 500 KB

english, 2009

38

Chemoprotective Properties of Phenylpropenoids, Bis(benzylidene)cycloalkanones, and Related Michael Reaction Acceptors: Correlation of Potencies as Phase 2 Enzyme Inducers and Radical Scavengers †

Dinkova-Kostova, Albena T., Abeygunawardana, Chitrananda, Talalay, Paul

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 362 KB

english, 1998

39

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

Casares, Laura, Unciti-Broceta, Juan Diego, Prados, Maria Eugenia, Caprioglio, Diego, Mattoteia, Daiana, Higgins, Maureen, Apendino, Giovanni, Dinkova-Kostova, Albena T., MuÃ±oz, Eduardo, de la Vega,

Journal:

Year:

2020

File:

PDF, 2.13 MB

2020

40

Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

Xiu Jun Wang, John D. Hayes, Larry G. Higgins, C. Roland Wolf, Albena T. Dinkova-Kostova

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 764 KB

english, 2010

41

Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets

Saito, Akira, Higgins, Maureen, Zheng, Suqing, Li, Wei, Ojima, Iwao, Dinkova-Kostova, Albena T., Honda, Tadashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 543 KB

english, 2013

42

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Tadashi Honda, Albena T. Dinkova-Kostova, Emilie David, Eric M. Padegimas, Chitra Sundararajan, Melean Visnick, Ron Bumeister, W. Christian Wigley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 529 KB

english, 2011

43

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

Albena T. Dinkova-Kostova, Paul Talalay

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 514 KB

english, 2010

44

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

Lingxiang Ye, Albena T Dinkova-Kostova, Kristina L Wade, Yuesheng Zhang, Theresa A Shapiro, Paul Talalay

Journal:

Clinica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

45

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Kovac, Stjepana, Angelova, Plamena R., Holmström, Kira M., Zhang, Ying, Dinkova-Kostova, Albena T., Abramov, Andrey Y.

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2015

Language:

english

File:

PDF, 882 KB

english, 2015

46

NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

Ghorab, Mostafa M., Alsaid, Mansour S., El-Gazzar, Marwa G., Higgins, Maureen, Dinkova-Kostova, Albena T., Shahat, Abdelaaty A.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 602 KB

english, 2016

47

Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

Dinkova-Kostova, Albena T, Kazantsev, Aleksey G

Journal:

Neurodegenerative Disease Management

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

48

Measuring the interaction of transcription factor Nrf2 with its negative regulator Keap1 in single live cells by an improved FRET/FLIM analysis

Dikovskaya, Dina, Appleton, Paul L., Bento-Pereira, Claudia, Dinkova-Kostova, Albena T.

Journal:

Chemical Research in Toxicology

Year:

2019

Language:

english

File:

PDF, 7.59 MB

english, 2019

49

Rapid body weight gain increases the risk of UV radiation–induced skin carcinogenesis in SKH-1 hairless mice

Albena T. Dinkova-Kostova, Jed W. Fahey, Stephanie N. Jenkins, Scott L. Wehage, Paul Talalay

Journal:

Nutrition Research

Year:

2008

Language:

english

File:

PDF, 222 KB

english, 2008

50

[Methods in Enzymology] Quinones and Quinone Enzymes, Part B Volume 382 || Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

Dinkova-Kostova, Albena T

Year:

2004

Language:

english

File:

PDF, 238 KB

english, 2004

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